Hidesaku Asakura Selected Research

Disseminated Intravascular Coagulation

3/2022	Coagulopathy and Fibrinolytic Pathophysiology in COVID-19 and SARS-CoV-2 Vaccination.
1/2022	Therapeutic Strategies for Disseminated Intravascular Coagulation Associated with Aortic Aneurysm.
1/2022	Recombinant human erythropoietin attenuates hepatic dysfunction by suppressing hepatocellular apoptosis in lipopolysaccharide-induced disseminated intravascular coagulation in rats.
10/2021	Potential of continuous tPA infusion for multiple-organ failure from lipopolysaccharide-induced disseminated intravascular coagulation in rats.
9/2021	Blue Rubber Bleb Nevus Syndrome Complicated by Enhanced-Fibrinolytic-Type DIC: A Case Report.
8/2021	Detailed exploration of pathophysiology involving inflammatory status and bleeding symptoms between lipopolysaccharide- and tissue factor-induced disseminated intravascular coagulation in rats.
7/2021	Effect of NOS Inhibitors and Anticoagulants on Nitric Oxide Production in a Tissue-factor Induced Rat DIC Model.
1/2021	COVID-19-associated coagulopathy and disseminated intravascular coagulation.
1/2021	Potential mechanisms of nafamostat therapy for severe COVID-19 pneumonia with disseminated intravascular coagulation.
1/2021	Management of disseminated intravascular coagulation associated with aortic aneurysm and vascular malformations.

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Hidesaku Asakura Research Topics

Disease

51	Disseminated Intravascular Coagulation 03/2022 - 01/2002
23	Hemorrhage 03/2022 - 06/2002
19	Thrombosis (Thrombus) 03/2022 - 09/2003
8	COVID-19 01/2022 - 01/2020
7	Sepsis (Septicemia) 01/2019 - 01/2004
6	Aortic Aneurysm (Aneurysm, Aortic) 01/2022 - 09/2005
6	Neoplasms (Cancer) 01/2020 - 03/2004
5	Acute Promyelocytic Leukemia 04/2016 - 09/2003
4	Thrombocytopenia (Thrombopenia) 03/2022 - 09/2005
4	Infections 01/2020 - 01/2005
3	Inflammation (Inflammations) 08/2021 - 10/2006
3	Pulmonary Embolism 01/2021 - 07/2014
3	Hemophilia A (Haemophilia) 09/2019 - 01/2010
3	Venous Thrombosis (Deep-Vein Thrombosis) 03/2017 - 10/2011
3	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 02/2015 - 04/2004
3	Hematologic Neoplasms (Hematological Malignancy) 10/2014 - 12/2007
3	Abdominal Aortic Aneurysm 10/2009 - 09/2005
3	Graft vs Host Disease (Graft-Versus-Host Disease) 08/2006 - 12/2005
2	Cytokine Release Syndrome 10/2021 - 01/2021
2	Hemangioma (Angioma) 09/2021 - 11/2005
2	Hyperkalemia 01/2021 - 02/2005
2	Disease Progression 01/2021 - 01/2020
2	Immunoglobulin Light-chain Amyloidosis 04/2020 - 09/2012
2	Cardiovascular Diseases (Cardiovascular Disease) 01/2019 - 01/2018
2	Thrombotic Microangiopathies 01/2019 - 05/2009
2	Liver Failure 01/2016 - 10/2011
2	Disease Susceptibility (Diathesis) 08/2015 - 01/2010
2	Myocardial Infarction 07/2014 - 09/2011
2	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 03/2014 - 08/2006
2	Lymphoma (Lymphomas) 03/2014 - 01/2006
2	Wounds and Injuries (Trauma) 06/2013 - 09/2003
2	Aneurysm (Aneurysms) 10/2009 - 01/2008
2	Leukemia 12/2007 - 12/2005
2	Bronchiolitis Obliterans Syndrome 02/2006 - 01/2006
2	Renal Cell Carcinoma (Grawitz Tumor) 02/2005 - 03/2004
1	Multiple Organ Failure (MODS) 10/2021
1	Blue rubber bleb nevus syndrome 09/2021
1	Vascular Malformations 01/2021
1	Pneumonia (Pneumonitis) 01/2021
1	Pancreatitis 01/2021
1	Hypoxia (Hypoxemia) 01/2021
1	Aplastic Anemia (Anemia, Hypoplastic) 06/2020
1	Periodontitis 06/2020

Drug/Important Bio-Agent (IBA)

48	Dacarbazine (DIC)FDA LinkGeneric 01/2022 - 06/2002
12	AnticoagulantsIBA 01/2022 - 01/2010
11	Heparin (Liquaemin)FDA LinkGeneric 01/2022 - 06/2002
11	LipopolysaccharidesIBA 01/2022 - 01/2002
10	Tranexamic Acid (AMCA)FDA Link 01/2022 - 06/2004
10	Hemostatics (Antihemorrhagics)IBA 01/2022 - 01/2002
9	Thromboplastin (Tissue Factor)IBA 08/2021 - 01/2002
8	AntithrombinsIBA 01/2021 - 09/2012
5	fibrin fragment D (D-dimer)IBA 03/2022 - 05/2004
4	Antifibrinolytic Agents (Antifibrinolytics)IBA 09/2021 - 09/2005
4	FibrinIBA 08/2021 - 10/2004
4	ThrombomodulinIBA 01/2019 - 03/2014
3	Fibrinogen (Factor I)FDA Link 03/2022 - 04/2003
3	Low-Molecular-Weight Heparin (Heparin, Low Molecular Weight)IBA 01/2022 - 10/2004
3	nafamostatIBA 01/2022 - 01/2020
3	Nitric Oxide (Nitrogen Monoxide)FDA Link 07/2021 - 10/2002
3	Factor X (Stuart Factor)IBA 01/2020 - 09/2012
3	CytokinesIBA 10/2008 - 09/2006
3	antithrombin III-protease complexIBA 10/2006 - 01/2002
3	Endothelins (Endothelin)IBA 04/2005 - 10/2002
2	VaccinesIBA 03/2022 - 01/2022
2	NG-Nitroarginine Methyl Ester (L-NAME)IBA 07/2021 - 01/2004
2	Thrombin FDA Link 07/2021 - 11/2016
2	prothrombin complex concentrates (PPSB)IBA 01/2020 - 01/2010
2	Aspirin (Acetylsalicylic Acid)FDA LinkGeneric 01/2018 - 09/2011
2	RivaroxabanIBA 11/2017 - 07/2014
2	Warfarin (Coumadin)FDA LinkGeneric 11/2017 - 10/2011
2	Blood Coagulation Factors (Coagulation Factor)IBA 01/2015 - 01/2010
2	Factor VII (Proconvertin)IBA 03/2012 - 01/2002
2	Annexin A2 (Annexin II)IBA 10/2009 - 01/2008
2	Inosine Triphosphate (ITP)IBA 05/2009 - 09/2006
2	danaparoid (Orgaran)FDA Link 11/2005 - 09/2005
1	Platelet Factor 4IBA 03/2022
1	COVID-19 VaccinesIBA 03/2022
1	ImmunosorbentsIBA 03/2022
1	EnzymesIBA 03/2022
1	AntibodiesIBA 03/2022
1	Erythropoietin FDA Link 01/2022
1	apixabanIBA 09/2021
1	Interleukin-6 (Interleukin 6)IBA 08/2021
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 08/2021
1	argatroban (MPQA)FDA Link 07/2021
1	N(6)-(1-iminoethyl)lysineIBA 07/2021
1	Nitric Oxide Synthase Type III (Endothelial Nitric Oxide Synthase)IBA 07/2021
1	Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)IBA 07/2021
1	Factor Xa InhibitorsIBA 07/2021
1	Antiviral Agents (Antivirals)IBA 01/2021
1	Serine Proteinase Inhibitors (Serine Protease Inhibitors)IBA 01/2021
1	idarucizumabIBA 06/2020
1	Factor XIII (Coagulation Factor XIII)IBA 06/2020
1	Immunoglobulin Light Chains (Immunoglobulin Light Chain)IBA 04/2020

Therapy/Procedure

14	Therapeutics 01/2022 - 09/2005
5	Drug Therapy (Chemotherapy) 01/2021 - 04/2004
3	Bone Marrow Transplantation (Transplantation, Bone Marrow) 12/2007 - 04/2004
3	Stem Cell Transplantation 12/2005 - 03/2004
1	Sclerotherapy 09/2021
1	Extracorporeal Membrane Oxygenation 12/2020